NVP-ADW742 b ( ADW;GSK 552602A;ADW742 )

Catalog No. M19445 CAS No. 475488-23-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

NVP-ADW742 b
Note

Research use only not for human use.
Brief Description

NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM >16-fold more potent against IGF-1R than InsR; little activity to HER2 PDGFR VEGFR-2 Bcr-Abl and c-Kit.
Description

NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM >16-fold more potent against IGF-1R than InsR; little activity to HER2 PDGFR VEGFR-2 Bcr-Abl and c-Kit.
Synonyms

ADW;GSK 552602A;ADW742
Pathway

Angiogenesis
Target

IGF-1R
Recptor

IGF-1R
Research Area

——
Indication

——

CAS Number

475488-23-4
Formula Weight

453.58
Molecular Formula

C28H31N5O
Purity

>98% (HPLC)
Solubility

DMSO:10 mg/mL (22.04 mM) warmed;Ethanol:3 mg/mL (6.61 mM);Water:<1 mg/mL
SMILES

C1CCN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6
Chemical Name

5-(3-(benzyloxy)phenyl)-7-((1r3r)-3-(pyrrolidin-1-ylmethyl)cyclobutyl)-7H-pyrrolo[23-d]pyrimidin-4-amine

1.Mitsiades CS et al. Cancer Cell 2004 5(3) 221-230.

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