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NVP-ADW742 b
CAS No. 475488-23-4
NVP-ADW742 b ( ADW;GSK 552602A;ADW742 )
Catalog No. M19445 CAS No. 475488-23-4
NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM >16-fold more potent against IGF-1R than InsR; little activity to HER2 PDGFR VEGFR-2 Bcr-Abl and c-Kit.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 61 | In Stock |
|
| 5MG | 96 | In Stock |
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| 10MG | 160 | In Stock |
|
| 25MG | 289 | In Stock |
|
| 50MG | 532 | In Stock |
|
| 100MG | 759 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNVP-ADW742 b
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NoteResearch use only not for human use.
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Brief DescriptionNVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM >16-fold more potent against IGF-1R than InsR; little activity to HER2 PDGFR VEGFR-2 Bcr-Abl and c-Kit.
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DescriptionNVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM >16-fold more potent against IGF-1R than InsR; little activity to HER2 PDGFR VEGFR-2 Bcr-Abl and c-Kit.
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SynonymsADW;GSK 552602A;ADW742
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PathwayAngiogenesis
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TargetIGF-1R
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RecptorIGF-1R
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Research Area——
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Indication——
Chemical Information
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CAS Number475488-23-4
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Formula Weight453.58
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Molecular FormulaC28H31N5O
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Purity>98% (HPLC)
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SolubilityDMSO:10 mg/mL (22.04 mM) warmed;Ethanol:3 mg/mL (6.61 mM);Water:<1 mg/mL
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SMILESC1CCN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6
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Chemical Name5-(3-(benzyloxy)phenyl)-7-((1r3r)-3-(pyrrolidin-1-ylmethyl)cyclobutyl)-7H-pyrrolo[23-d]pyrimidin-4-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Mitsiades CS et al. Cancer Cell 2004 5(3) 221-230.
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NVP-ADW742 b
NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM >16-fold more potent against IGF-1R than InsR; little activity to HER2 PDGFR VEGFR-2 Bcr-Abl and c-Kit.
